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IgG anti-hinge antibodies against IgG4 F(ab’)2 fragments generated using pepsin are useful diagnostic markers for rheumatoid arthritis: implications of the possible roles of metalloproteinases and IgG subclasses in generating of immunogenic hinge epitopes.

2020-06-05

Abstract excerpt

<title>Abstract</title> <p><bold>Background.</bold> Pepsin agglutinators, discovered over 50 years ago, have been recently referred to as anti-hinge antibodies (AHAs) because of their reaction with the IgG hinge epitope. AHAs have different reactivity for each hinge epitope generated by each protease that cleaves the hinge region at different sites. Moreover, AHAs have different reactivity against different hinge...

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Literature Corpus work
cbb7fc19-1761-5538-8bad-a731830e4830
DOI
10.21203/rs.2.21747/v4
Open publication

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IgG anti-hinge antibodies against IgG4 F(ab’)2 fragments generated using pepsin are useful diagnostic markers for rheumatoid arthritis: implications of the possible roles of metalloproteinases and IgG subclasses in generating of immunogenic hinge epitopes.DOI 10.21203/rs.2.21747/v4
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