Article

Structure-guided engineering of CCL27 enhances natural ligand CAR T-cells against CCR10 for multiple myeloma

2025-08-23

Abstract excerpt

Despite the success of BCMA CAR-Ts, many multiple myeloma patients relapse and require additional therapeutic options. Our group previously identified the chemokine receptor CCR10 as a potential alternate target to address this need. Here, we validated CCR10 expression on primary myeloma tumors and sought to develop CAR T-cells against CCR10, utilizing its natural ligand CCL27 as a CAR binding element. However, CA...

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Identifiers and source

Literature Corpus work: cba04e8e-7441-5124-98cd-e77985277887
DOI: 10.1101/2025.08.19.670119

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