Article

Targeting high-risk multiple myeloma genotypes with optimized anti-CD70 CAR-T cells

2024-02-28

Abstract excerpt

Despite the success of BCMA-targeting CAR-Ts in multiple myeloma, patients with high-risk cytogenetic features still relapse most quickly and are in urgent need of additional therapeutic options. Here, we identify CD70, widely recognized as a favorable immunotherapy target in other cancers, as a specifically upregulated cell surface antigen in high risk myeloma tumors. We use a structure-guided design to define a...

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Literature Corpus work: 49fc4df5-a01b-5fd9-9100-12d7a2931b44
DOI: 10.1101/2024.02.24.581875

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