Article

Single-cell Transcriptome Reveals Peripheral Proinflammatory Signatures and a ZFP36L2- Dependent Therapeutic Pathway in Adult-onset Still's Disease

2026-05-21

Abstract excerpt

<title>Abstract</title> <p>Adult-onset Still's Disease (AOSD) is a heterogeneous autoinflammatory disease with complex dysfunction of multiple immune cells. By single cell transcriptome analysis, we profiled the peripheral immune landscape of AOSD. There were significant alterations of the composition and heterogeneity of peripheral immune cells in AOSD. Specially, the increased neutrophils were clustered to five...

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Literature Corpus work: cb7dddaa-4a8d-5dcd-a834-58888af6e264
DOI: 10.21203/rs.3.rs-9542923/v1

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