Back to search

Article

Neuropathological Correlates of Apathy Progression in Alzheimer’s Disease and Related Dementias: A Longitudinal NACC Cohort Study

2025-11-10

Abstract excerpt

<h4>Objective</h4> Apathy is a prevalent and disabling symptom in Alzheimer’s disease and related dementias, yet its progression across neuropathological subtypes remains incompletely understood. This cohort study investigates longitudinal changes in apathy and their associations with major neuropathologies using data from the National Alzheimer’s Coordinating Center. <h4>Methods</h4> We analyzed 1,488 participa...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
cb71b2ac-98dd-50d7-8e69-486d7a1f5817
DOI
10.1101/2025.11.06.686966
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Neuropathological Correlates of Apathy Progression in Alzheimer’s Disease and Related Dementias: A Longitudinal NACC Cohort StudyDOI 10.1101/2025.11.06.686966
Apathy and Affective Symptoms Associated with Elevated Alzheimer’s Disease BiomarkersSemantic proximity
Apathy in presymptomatic genetic frontotemporal dementia predicts cognitive decline and is driven by structural brain changes.Semantic proximity
Self-versus caregiver-reported apathy across neurological disordersSemantic proximity
A DATA-DRIVEN EXAMINATION OF APATHY AND DEPRESSIVE SYMPTOMS IN DEMENTIA WITH INDEPENDENT REPLICATIONSemantic proximity
Atrophy subtypes and the ATN classification scheme in Alzheimer’s diseaseSemantic proximity
Cerebral amyloid angiopathy and Alzheimer's and related pathologies across APOE genotypes.Semantic proximity
Toward Precision Neuropsychiatry of Dementia: Neuropsychiatric Symptoms as Multidimensional Clinical Phenotypes.Semantic proximity
Cerebral amyloid angiopathy and its co-occurrence with Alzheimer's disease and other cerebrovascular neuropathologic changes.Semantic proximity
The Pathology, Alzheimer’s and Related Dementias Study (PARDoS): Design and Characteristics of the First 4700+ Brazilian ParticipantsSemantic proximity
The Ontario Neurodegenerative Disease Research InitiativeSemantic proximity
Comorbid neuropathological diagnoses in early vs late-onset Alzheimer’s diseaseSemantic proximity
Alzheimer’s Disease Neuropathological Comorbidities Are Common in the Younger-OldSemantic proximity
Select a neighboring publication to make it the new centre.