Article

Social Factors of Health Covary with Population Stratification and Confound Heritability Estimates

2025-06-13

Abstract excerpt

Social factors of health (SFOH) are critical determinants of human traits but are rarely incorporated into genetic models. Here, we assess how participant-completed SFOH survey data influence heritability estimates and trait variance in 85,963 diverse All of Us participants spanning multiple ancestries and racial identities. We summarized SFOH survey data using multiple correspondence analysis (MCA) into axes repr...

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Literature Corpus work: caf21e77-bab1-589e-bea2-70faf1dbe642
DOI: 10.1101/2025.06.12.659317

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