Endogenous antimicrobial peptides in human colostrum: a peptidomics study by liquid-chromatography high-resolution mass-spectrometry (LC-HRMS) and bioinformatics

Abstract excerpt

Human colostrum is recognized as a source of bioactive compounds that impact on neonatal development, such as antimicrobial peptides. Antimicrobial peptides (AMPs) present some common characteristics, as they are relatively small (<10 kDa), most of them are positively charged and possess α-helical regions. These molecules can protect the newborn against infectious agents such as bacteria, fungi, and viruses. Using...

Topics

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• Amino Acid Sequence
• Antimicrobial Peptides and Activities
• Breastfeeding Practices and Influences
• Cathelicidins
• Genetic Variation
• Infant Nutrition and Health
• Peptidase Inhibition and Analysis
• Protein Hydrolysis and Bioactive Peptides

Identifiers and source

Literature Corpus work

caaee5f9-7e0e-5318-aa30-ee8acecb1a3d

DOI

10.1101/2025.02.03.636292