Article

SLC35G3 is a UDP-N-acetylglucosamine transporter for sperm glycoprotein formation and underpins male fertility in mice

2025-05-15

Abstract excerpt

Despite the recognized importance of glycans in biological phenomena, their complex roles in spermatogenesis and sperm function remain unclear. SLC35G3, a 10-transmembrane protein specifically found in early round spermatids, belongs to the sugar-nucleotide transporter family, indicating its involvement in glycan formation. In this study, we found that Slc35g3 knockout male mice were sterile due to impaired sperm...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ca10193f-a0e5-5e7c-aa69-1338857633e6
DOI: 10.1101/2025.05.12.653469

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SLC35G3 is a UDP-N-acetylglucosamine transporter for sperm glycoprotein formation and underpins male fertility in miceDOI 10.1101/2025.05.12.653469Read

Biological Functions and Large-Scale Profiling of Protein Glycosylation in Human SemenSemantic proximity Read

DPAGT1‐Mediated Protein N‐Glycosylation Is Indispensable for Oocyte and Follicle Development in MiceSemantic proximity Read

Complex N-Glycans Are Essential, but Core 1 and 2 Mucin O-Glycans, O-Fucose Glycans, and NOTCH1 Are Dispensable, for Mammalian Spermatogenesis1Semantic proximity Read

1700029I15Rik orchestrates the biosynthesis of acrosomal membrane proteins required for sperm–egg interactionSemantic proximity Read

Spatial Organization of the Sperm Cell GlycoproteomeSemantic proximity Read

Slc26a3 deficiency is associated with epididymis dysplasia and impaired sperm fertilization potential in the mouse.Semantic proximity Read

A heterozygous mutation of GALNTL5 affects male infertility with impairment of sperm motility.Semantic proximity Read

Mapping of the N-Linked Glycoproteome of Human SpermatozoaSemantic proximity Read

Glycosylation related actions of glycodelin: gamete, cumulus cell, immune cell and clinical associationsSemantic proximity Read

Sialylation: fate decision of mammalian sperm development, fertilization, and male fertilitySemantic proximity Read

Expression and distribution of CD151 as a partner of alpha6 integrin in male germ cellsSemantic proximity Read

Prss55 but not Prss51 is required for male fertility in mice†Semantic proximity Read