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Article

A heterozygous mutation of GALNTL5 affects male infertility with impairment of sperm motility.

Proceedings of the National Academy of Sciences of the United States of America - 21 Jan 2014

Takasaki Nobuyoshi, Tachibana Kouichi, Ogasawara Satoshi, Matsuzaki Hideki, Hagiuda Jun, Ishikawa Hiromichi, Mochida Keiji, Inoue Kimiko, Ogonuki Narumi, Ogura Atsuo, Noce Toshiaki, Ito Chizuru, Toshimori Kiyotaka, Narimatsu Hisashi

Abstract excerpt

For normal fertilization in mammals, it is important that functionally mature sperm are motile and have a fully formed acrosome. The glycosyltransferase-like gene, human polypeptide N-acetylgalactosaminyltransferase-like protein 5 (GALNTL5), belongs to the polypeptide N-acetylgalactosamine-transferase (pp-GalNAc-T) gene family because of its conserved glycosyltransferase domains, but it uniquely truncates the...

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Source

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Identifiers

PMID: 24398516
DOI: 10.1073/pnas.1310777111
PMCID: PMC3903224

Genes

GALNTL5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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