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Article

Cold induces shifts of voltage dependence in mutant SCN4A, causing hypokalemic periodic paralysis.

Neurology - 14 Oct 2003

Sugiura Y, Makita N, Li L, Noble P J, Kimura J, Kumagai Y, Soeda T, Yamamoto T

Abstract excerpt

BACKGROUND: The authors reported a mutation, P1158S, of the human skeletal muscle sodium channel gene (SCN4A) in a family with cold-induced hypokalemic periodic paralysis (hypoKPP) and myotonia. OBJECTIVE: To identify mechanisms of temperature dependency in this channelopathy. METHODS: Using the amphotericin B perforated patch clamp method, sodium currents were recorded at 22 and 32 degrees C from the wild-type...

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Source

Identifiers

PMID: 14557559
DOI: 10.1212/01.wnl.0000086820.54065.a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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