Article

Independent prognostic value of a 4-gene transcriptomic signature in lung adenocarcinoma across five external cohorts

2026-08-04

Abstract excerpt

<title>Abstract</title> <p> <bold>Background.</bold> Transcriptomic prognostic signatures for lung adenocarcinoma are frequently reported with in-sample discrimination and without independent external validation, and are prone to feature-selection leakage and undisclosed model selection. We asked whether a pre-specified, leakage-free signature adds prognostic value beyond standard-of-care staging, and whether i...

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Literature Corpus work: ca044515-8e32-58ba-9017-d6c5cd04f1fd
DOI: 10.21203/rs.3.rs-10490641/v1

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