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Recommendations for Validating Omics Prediction Models: Insights from a Lung Cancer RNA Biomarker Study

12 Aug 2025

Abstract excerpt

BACKGROUND: External validation of predictive models in medical research is crucial to ensure their generalizability and applicability across diverse populations. However, validation often reveals discrepancies in model performance due to cohort differences, sample collection and storage, overfitting, and inconsistencies in data handling. This study investigates the challenges encountered during external...

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PMID: 40794097
DOI: 10.1158/1055-9965.epi-25-0787

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