Article

Blood-based transcriptomic classification of lung cancer: a leakage-free nested cross-validation framework with LASSO

2026-07-13

Abstract excerpt

Peripheral whole-blood gene expression profiling offers a minimally invasive route to lung cancer detection, but high-dimensional transcriptomic data are prone to optimistic bias when preprocessing and model selection are not properly separated from performance evaluation. We applied ℓ 1 -penalised (LASSO) logistic regression to 303 peripheral whole-blood microarray profiles (123 lung cancer cases and 180 healthy...

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Literature Corpus work: a432aa89-2bcf-5414-9fdd-93e6ab62e27b
DOI: 10.64898/2026.07.11.26357823

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