Article

Novel Functional Features of cGMP Substrate Proteins IRAG1 and IRAG2

2023-05-17

Abstract excerpt

The inositol triphosphate associated proteins IRAG1 and IRAG2 are cGMP kinase substrate proteins, which regulate intracellular Ca2+. Previously, IRAG1 was discovered as a 125 kDa membrane protein at the endoplasmic reticulum, that is associated with the intracellular Ca2+ channel IP3R-I and the PKGIβ and inhibits IP3R-I upon PKGIβ-mediated phosphorylation. IRAG2 is a 75 kDa membrane protein homologue of IRAG1 and...

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Identifiers and source

Literature Corpus work: c95fa020-120c-5cab-ba1d-11e7e376cf21
DOI: 10.20944/preprints202305.1221.v1

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