Article

Anti-CD47 immunotherapy as a therapeutic strategy for the treatment of breast cancer brain metastasis

2023-07-25

Abstract excerpt

The presence of cell surface protein CD47 allows cancer cells to evade innate and adaptive immune surveillance resulting in metastatic spread. CD47 binds to and activates SIRPα on the surface of myeloid cells, inhibiting their phagocytic activity. On the other hand, CD47 binds the matricellular protein Thrombospondin-1, limiting T-cell activation. Thus, blocking CD47 is a potential therapeutic strategy for prevent...

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Literature Corpus work: c8f6102e-b2bc-56c9-aa41-cda1f3c1c30c
DOI: 10.1101/2023.07.25.550566

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