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Article

The molecular mechanism underlying KRAS regulation on STK31 expression in pancreatic ductal adenocarcinoma.

Cancer science - 1 Oct 2024

Liu Yuting, Tang Shing Chun, Li Chi Han, To Ka Fai, Li Bo, Chan Stephen Lam, Wong Chi Hin, Chen Yangchao

Abstract excerpt

KRAS gene mutations are common in pancreatic ductal adenocarcinoma (PDAC), but targeting mutant KRAS is still challenging. Here, an endoribonuclease-prepared small interfering RNA (esiRNA) library was used to screen new kinases that play critical roles in PDAC driven by KRAS gene mutations, and serine/threonine kinase 31 (STK31) was identified and characterized as a potential therapeutic target for KRAS-mutant...

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Share to Carcinoma, Pancreatic Ductal
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Proliferation

Share to Gene Expression Regulation, Neoplastic

Share to MAP Kinase Signaling System

Share to Pancreatic Neoplasms

Share to Protein Serine-Threonine Kinases

Share to Proto-Oncogene Proteins p21(ras)

Source

Open in PubMed Open full text

Identifiers

PMID: 39054797
DOI: 10.1111/cas.16286
PMCID: PMC11447899

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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