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Clinical and Genetic Spectrum of SCN8A-Related Disorders: A Retrospective Study From the Gulf Region.

Journal of child neurology - 1 Aug 2026

Muthaffar Osama, Alsubhan Mashael, Mir Ali, Alsharhan Hind, Ayed Mariam, Zakkariah Mohamed, Elshafie Reem, Futaisi Amna Al, Bamaga Ahmed, Hundallah Khalid, Saadi Nebal, Oshi Mohammed, Tabarki Brahim, Alsini Hanin, Helali Hadi A, Babiker Mohamed, Almuntaser Samar, Alyazidi Anas

Abstract excerpt

This multicenter retrospective study examined the clinical characteristics and outcomes of 26 patients with sodium channel protein type 8 subunit alpha (SCN8A)-related epilepsy and/or neurodevelopmental disorders across the Gulf region. Data were collected from August 2024 to January 2025. Most patients (80.77%) experienced epilepsy onset within the first year of life, with a mean onset age of 8.25 months. Common...

Topics

Adolescent
Child
Child, Preschool
Female
Humans
Infant
Male
Young Adult
Epilepsy
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

NAV1.6 Voltage-Gated Sodium Channel

Neurodevelopmental Disorders

Retrospective Studies

Middle East

Source

Identifiers

PMID: 41325016
DOI: 10.1177/08830738251396198

Genes

SCN8A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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