Article

Unraveling interindividual differences and functional consequences of gut microbial metabolism of immunosuppressants

2024-03-28

Abstract excerpt

A major challenge in kidney transplantation (KT) is the large interpatient variability in the pharmacokinetics of immunosuppressive drugs. Here, we explored the role of the gut microbiome in interindividual variation in immunosuppressive drug metabolism. Analysis of 38 fecal communities, including 10 from KT recipients, and 45 bacterial species against 25 drugs, revealed significant interindividual and drug-specif...

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Identifiers and source

Literature Corpus work: c855241e-14a9-5419-abf8-4f2e44668290
DOI: 10.1101/2024.03.28.586928

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