Article

Suppressive effect of ethyl acetate extract of Paecilomyces japonica on cell cycle progression of human acute leukemia Jurkat T cell clone overexpressing Bcl-2

2007-01-01

Abstract excerpt

To understand antitumor activity of an edible mushroom Paecilomyces japonica, we have investigated its effect on the cell cycle. When Jurkat T cells transfected with vector (JT/Neo) or Bcl-2 gene (JT/Bcl-2) were treated with the ethyl acetate extract (4-6 μg/ml) of P. japonica for 40 h, JT/Neo cells underwent apoptosis with no detectable G1-arrest, whereas JT/Bcl-2 cells that failed to induce apoptosis accumulated...

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Literature Corpus work: c853cee7-e4e7-5d44-a803-0c049817f706
DOI: 10.1016/j.foodchem.2005.09.026

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