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Article

The flavonoid Casticin has multiple mechanisms of tumor cytotoxicity action.

Cancer letters - 28 Oct 2006

Haïdara Khadidja, Zamir Lolita, Shi Qui-Wen, Batist Gerald

Abstract excerpt

We studied the mechanism of anti-tumor activity of the flavonoid Casticin, derived from Achillea millefolium. Casticin anti-tumor activity results in cell growth arrest in G2/M and in apoptotic death. As a tubulin-binding agent (TBA), Casticin induces p21, which in turn inhibits Cdk1. Moreover, Casticin appears to down regulate cyclin A. These observations could explain Casticin-induced G2/M arrest. Following...

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PMID: 16387422
DOI: 10.1016/j.canlet.2005.11.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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