Article
Beyond reference bias: Making pangenomes accessible with PangyPlot
2025-11-03
Abstract excerpt
Linear reference genomes have standardized genomics research but remain limited by reference bias, which skews read mapping and variant discovery. This bias can distort the interpretation of genetic variation, particularly for populations that are genetically distant from the reference. Pangenome graphs, such as those generated by the Human Pangenome Reference Consortium (HPRC), mitigate this limitation by integra...
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Identifiers and source
- Literature Corpus work
- c71600b5-1191-57d8-9158-5e7c5eab8bc0
- DOI
- 10.1101/2025.10.31.684064