Article

The Influence of TDP1 Inhibitor Usnic Acid Derivative OL9-116 on the Effects of Topotecan in Human Cells

2025-12-03

Abstract excerpt

Tyrosyl-DNA phosphodiesterase 1 (TDP1) is a key enzyme for the repair of stalled topoisomerase 1 (TOP1)-DNA complexes. We previously developed a TDP1 inhibitor, compound OL9-116, which is capable of enhancing the action of the anticancer drug topotecan (TPC), a TOP1 poison, in vitro and in vivo. In this study, the inhibition mode of OL9-116 (uncompetitive) was investigated. N-terminal domain of TDP1, which is impo...

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Literature Corpus work: c70f1b5c-9b1a-5984-b153-899fce2dee2c
DOI: 10.20944/preprints202512.0256.v1

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