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Carbohydrate linked organotin( iv ) complexes as human topoisomerase Iα inhibitor and their antiproliferative effects against the human carcinoma cell line

19 Nov 2013

Abstract excerpt

Dimethyltin(IV) complexes with ethanolamine (1) and biologically significant N-glycosides (2 and 3) were designed and synthesized. The structural elucidation of complexes 1-3 was done using elemental and spectroscopic methods; in addition, complex 1 was studied by single crystal X-ray diffraction studies. The in vitro DNA binding profile of complexes 2 and 3 was carried out by employing different biophysical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 24310209
DOI: 10.1039/c3dt51973b

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