Article

In vivo vaccination with cell line-derived whole tumor lysates – neoantigen quality, not quantity matters

2020-10-13

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Cancer vaccines provide a complex source of neoantigens. Still, increasing evidence reveals that the neoantigen quality rather than the quantity is predictive for treatment outcome. <bold>Methods: </bold>Using the preclinical Mlh1<sup>-/-</sup> tumor model, we performed a <italic>side-by side</italic> comparison of two autologous cell-line derived tumor lysates...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c6c2fca0-0980-5214-91d8-40ab6a5ba2dd
DOI: 10.21203/rs.3.rs-51223/v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

In vivo vaccination with cell line-derived whole tumor lysates – neoantigen quality, not quantity mattersDOI 10.21203/rs.3.rs-51223/v2Read

Rethinking Antigen Source: Cancer Vaccines Based on Whole Tumor Cell/tissue Lysate or Whole Tumor CellSemantic proximity Read

Neoantigen Cancer Vaccines: Real Opportunity or Another Illusion?Semantic proximity Read

Cancer Vaccines: Recent Insights and Future DirectionsSemantic proximity Read

Advancement insights in cancer vaccines: mechanisms, types, and clinical applicationsSemantic proximity Read

The spontaneous neoantigen-specific CD4 <sup>+</sup> T cell response to a growing tumor is functionally and phenotypically diverseSemantic proximity Read

The repertoire of human tumor-associated epitopes — identification and selection of antigens and their application in clinical trialsSemantic proximity Read

Strategies for developing and optimizing cancer vaccinesSemantic proximity Read

Systemic neoantigen-specific T cells reveal central determinants of PD-(L)1 blockade efficacySemantic proximity Read

Bedside formulation of a personalized multi-neoantigen vaccine against mammary carcinomaSemantic proximity Read

Vaccination rescues dysfunctional T cell therapy by amplifying rare stem-like antitumor CD8⁺ T cellsSemantic proximity Read

Genotype of Immunologically Hot or Cold Tumors Determines the Antitumor Immune Response and Efficacy by Fully Virulent Retargeted oHSV.Semantic proximity Read

Therapeutic Effects of a Neoantigen Vaccine With an Immune Checkpoint Inhibitor in a Cisplatin-Treated Mouse ModelSemantic proximity Read