Article

Iterative Refinement of Cellular Identity from Single-Cell Data Using Online Learning

2020-01-17

Abstract excerpt

Recent experimental advances have enabled high-throughput single-cell measurement of gene expression, chromatin accessibility and DNA methylation. We previously used integrative non-negative matrix factorization (iNMF) to jointly learn interpretable low-dimensional representations from multiple single-cell datasets using dataset-specific and shared metagene factors. These factors provide a principled, quantitative...

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Literature Corpus work: c6bd5380-1e58-5bd6-926a-06d596cbfb1d
DOI: 10.1101/2020.01.16.909861

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