Article

PRSformer: Disease Prediction from Million-Scale Individual Genotypes

2025-10-27

Abstract excerpt

Predicting disease risk from DNA presents an unprecedented emerging challenge as biobanks approach population scale sizes ( N > 10 6 individuals) with ultra-high-dimensional features ( L > 10 5 genotypes). Current methods, often linear and reliant on summary statistics, fail to capture complex genetic interactions and discard valuable individual-level information. We introduce PRSformer , a scalable deep lear...

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Literature Corpus work: c6541297-2b31-5f27-9e9c-ddf3a3df6bb8
DOI: 10.1101/2025.10.26.684578

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