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Characteristics of premanufacture CD8+ T cells determine CAR-T efficacy in patients with diffuse large B-cell lymphoma

25 Oct 2023

Abstract excerpt

Abstract Although chimeric antigen receptor (CAR) T cells have become an important treatment option for patients with relapsed/refractory B-cell malignancies, more than 60% of patients with diffuse large B-cell lymphoma (DLBCL) treated with CAR-T cell therapies fail to achieve a durable response. To reveal changes in CAR-T cell therapy and identify response biomarkers, we conducted a retrospective analysis of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37875502
DOI: 10.1038/s41392-023-01659-2

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