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Gene regulation modules in non-alcoholic fatty liver disease revealed by single-nucleus ATAC-seq

2022-07-13

Abstract excerpt

We investigated the progression of non-alcoholic fatty liver disease (NAFLD) from fatty liver to steatohepatitis using single-nucleus and bulk ATAC-seq on the livers of rats fed a high-fat diet (HFD). Rats fed HFD for 4 weeks developed fatty liver, and those fed HFD for 8 weeks further progressed to steatohepatitis. We observed an increase in the proportion of inflammatory macrophages, consistent with the patholog...

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Literature Corpus work
c6146a0b-46c6-5e39-bb9e-f45fa186f0d5
DOI
10.1101/2022.07.12.499681
Open publication

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Gene regulation modules in non-alcoholic fatty liver disease revealed by single-nucleus ATAC-seqDOI 10.1101/2022.07.12.499681
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