Article
Abnormal neovascular and proliferative conjunctival phenotype in limbal stem cell deficiency is associated with altered microRNA and gene expression modulated by PAX6 mutational status in congenital aniridia.
The ocular surface - 1 Jan 2021
Latta L, Ludwig N, Krammes L, Stachon T, Fries F N, Mukwaya A, Szentmáry N, Seitz B, Wowra B, Kahraman M, Keller A, Meese E, Lagali N, Käsmann-Kellner B
Abstract excerpt
PURPOSE: To evaluate conjunctival cell microRNA (miRNAs) and mRNA expression in relation to observed phenotype of progressive limbal stem cell deficiency in a cohort of subjects with congenital aniridia with known genetic status. METHODS: Using impression cytology, bulbar conjunctival cells were sampled from 20 subjects with congenital aniridia and 20 age and sex-matched healthy control subjects. RNA was...
Topics
- Aniridia
- Conjunctiva
- Eye Proteins
- Gene Expression
- Humans
- MicroRNAs
- Mutation
- PAX6 Transcription Factor
- Phenotype
- Phosphatidylinositol 3-Kinases
- Stem Cells