Article

Single and Multi-Objective Optimization of De Novo Drug Design for Sophisticated Biomarkers, RET Alterations

2026-02-27

Abstract excerpt

<title>Abstract</title> <p> Biomarker based oncology therapeutics leverage molecular signatures to identify patient populations most likely to benefit from a specific treatment, thereby increasing clinical success rates. Despite the significant merits of these biomarkers, the high rate of mutations across various therapeutic markers continues to impede innovative drug design. RET is a complex therapeutic biomark...

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Literature Corpus work: c5c5dd82-fa70-577a-811d-61a5f7f1c3b3
DOI: 10.21203/rs.3.rs-8916489/v1

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