Article

EvoSynth: Enabling Multi-Target Drug Discovery through Latent Evolutionary Optimization and Synthesis-Aware Prioritization

2025-11-05

Abstract excerpt

<h4>ABSTRACT</h4> Complex diseases, such as cancer and neurodegeneration, feature interconnected pathways, making single-target therapies ineffective due to pathway redundancy and compensatory mechanisms. Polypharmacy, which combines multiple drugs to target distinct proteins, addresses this but often leads to drug-drug interactions, cumulative toxicity, and complex pharmacokinetics. To overcome these challenges,...

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Literature Corpus work: 9e85d602-011b-5301-b56c-4a459c08a465
DOI: 10.1101/2025.11.04.686584

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