Article

Design, Immunogenicity and Preclinical Efficacy of the ChAdOx1.COVconsv12 Pan-Sarbecovirus T-cell Vaccine

2024-08-02

Abstract excerpt

During the COVID-19 pandemic, antibody-based vaccines targeting the SARS-CoV-2 spike glycoprotein were the key focus for development because neutralizing antibodies were associated with protection against the SARS-CoV-2 infection in pre-clinical models and human trials. While deploying these spike-based vaccines saved millions of lives worldwide, it has become clear that the immunological mechanisms of protection...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c5a0df2b-6362-5af8-81d6-3c06ea1bdae8
DOI: 10.20944/preprints202408.0038.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Design, Immunogenicity and Preclinical Efficacy of the ChAdOx1.COVconsv12 Pan-Sarbecovirus T-cell VaccineDOI 10.20944/preprints202408.0038.v1Read

A Single Chimeric Spike Antigen Induces Pan-Sarbecovirus ImmunitySemantic proximity Read

A conserved region T-cell vaccine for SarbecovirusesSemantic proximity Read

A Multi-Antigen Broad-Spectrum Coronavirus Vaccine Induces Potent and Durable Cross- Protection Against Infection and Disease Caused by Multiple SARS-CoV-2 VariantsSemantic proximity Read

Design, immunogenicity, and efficacy of a pan-sarbecovirus dendritic-cell targeting vaccineSemantic proximity Read

Design, immunogenicity, and efficacy of a pan-sarbecovirus dendritic-cell targeting vaccineSemantic proximity Read

Synthetic Multiantigen MVA Vaccine COH04S1 Protects Against SARS-CoV-2 in Syrian Hamsters and Non-Human PrimatesSemantic proximity Read

Efficacy of ChAdOx1 vaccines against SARS-CoV-2 Variants of Concern Beta, Delta and Omicron in the Syrian hamster modelSemantic proximity Read

Fusion protein pan-sarbecovirus vaccines elicit broadly protective immune responses targeting Clade 1a, 1b, and 3 sarbecovirusesSemantic proximity Read

Live-attenuated vaccine sCPD9 elicits superior mucosal and systemic immunity to SARS-CoV-2 variants in hamstersSemantic proximity Read

The ChAdOx1 vectored vaccine, AZD2816, induces strong immunogenicity against SARS-CoV-2 Beta (B.1.351) and other variants of concern in preclinical studiesSemantic proximity Read

Targeting Multiple Conserved T-Cell Epitopes for Protection against COVID-19 Moderate-Severe Disease by a Pan-Sarbecovirus VaccineSemantic proximity Read

Evolving SARS-CoV-2 Vaccines: From Current Solutions to Broad-Spectrum ProtectionSemantic proximity Read