Article

Recombinant Humanized Collagen Type I Promotes Oral Ulcer Healing via HGF/TGF-β3-Mediated Fibroblast Activation

2026-08-21

Abstract excerpt

<title>Abstract</title> <p> Oral ulcers located on the ventral tongue present considerable therapeutic challenges, attributable to persistent mechanical friction and continuous salivary washout. In this study, the therapeutic efficacy of recombinant humanized collagen type I (rhCol I) was evaluated using an acetic acid-induced mouse model of ventral tongue ulceration. Topical administration of rhCol I significan...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c594663c-a502-5b32-806f-6c4a7c061bf9
DOI: 10.21203/rs.3.rs-10604926/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Recombinant Humanized Collagen Type I Promotes Oral Ulcer Healing via HGF/TGF-β3-Mediated Fibroblast ActivationDOI 10.21203/rs.3.rs-10604926/v1Read

Mapping Connective Tissue Molecular Blueprints to Illuminate Human Keratinized and Non-Keratinized Oral MucosaSemantic proximity Read

Characterization of recombinant humanized collagen type III and its influence on cell behavior and phenotypeSemantic proximity Read

Human Gingival Fibroblasts Display a Non-Fibrotic Phenotype Distinct from Skin Fibroblasts in Three-Dimensional CulturesSemantic proximity Read

Recent Advances in Wound Healing, Tissue Repair, Regeneration and Scar ManagementSemantic proximity Read

Exosomal miR-17-5p derived from epithelial cells is involved in aberrant epithelium-fibroblast cross-talk and induces the development of oral submucosal fibrosisSemantic proximity Read

The diverse role of oral fibroblasts in normal and diseaseSemantic proximity Read

Exosomal miR-17-5p derived from epithelial cells is involved in aberrant epithelium-fibroblast crosstalk and induces the development of oral submucosal fibrosisSemantic proximity Read

Human gingiva transcriptome during wound healingSemantic proximity Read

Development and Characterization of In Vitro Human Oral Mucosal Equivalents Derived from Immortalized Oral KeratinocytesSemantic proximity Read

Development of a highly effective recombinant protein from human collagen type III Alpha 1 (COL3A1) to enhance human skin cell functionalitySemantic proximity Read

Hypoxia-Preconditioned Human Dental Pulp Mesenchymal Stem Cell Secretome Enhances Tissue Regeneration in a Medicinal Leech Wound ModelSemantic proximity Read

Phenotypic differences between oral and skin fibroblasts in wound contraction and growth factor expression.Semantic proximity Read