Article

Iterative feature selection method to discover predictive variables and interactions for high-dimensional transplant genomic data

2019-04-18

Abstract excerpt

After allogeneic hematopoietic stem cell transplantation (allo-HCT), donor-derived immune cells can trigger devastating graft-versus-host disease (GVHD). The clinical effects of GVHD are well established; however, genetic mechanisms that contribute to the condition remain unclear. Candidate gene studies and genome-wide association studies have shown promising results, but they are limited to a few functionally der...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c567a6ba-4d50-5b5b-bf36-36d670d3b953
DOI: 10.1101/605428

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Iterative feature selection method to discover predictive variables and interactions for high-dimensional transplant genomic dataDOI 10.1101/605428Read

TRM: a powerful two-stage machine learning approach for identifying SNP-SNP interactions.Semantic proximity Read

Feature Selection and Molecular Classification of Cancer Phenotypes: A Comparative Study.Semantic proximity Read

Multiple single-nucleotide polymorphism-based risk model for clinical outcomes after allogeneic stem-cell transplantation, especially for acute graft-versus-host disease.Semantic proximity Read

Systematic mining and quantification reveal the dominant contribution of non-HLA variations to acute graft-versus-host disease.Semantic proximity Read

Gene-gene interaction filtering with ensemble of filters.Semantic proximity Read

Efficient feature selection on gene expression data: Which algorithm to use?Semantic proximity Read

An Integrative Multi-Omics Random Forest Framework for Robust Biomarker DiscoverySemantic proximity Read

SNP interaction detection with Random Forests in high-dimensional genetic data.Semantic proximity Read

Selecting Feature Subsets Based on SVM-RFE and the Overlapping Ratio with Applications in Bioinformatics.Semantic proximity Read

Marker genes of incident type 1 diabetes in peripheral blood mononuclear cells of children: A machine learning strategy for large-p, small-n scenariosSemantic proximity Read

Supervised learning-based tagSNP selection for genome-wide disease classifications.Semantic proximity Read

Identification by random forest method of HLA class I amino acid substitutions associated with lower survival at day 100 in unrelated donor hematopoietic cell transplantationSemantic proximity Read