Article

Electrochemical Metabolic Profiling Reveals Mitochondrial Hyperactivation and Enhanced Neural Progenitor Proliferation in MLC1-Mutant Human Cortical Organoids

2025-04-20

Abstract excerpt

<h4>SUMMARY</h4> Mitochondrial function is critical for neural progenitor regulation, yet its dysregulation during early human brain development remains poorly defined. Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is a neurodevelopmental disorder caused by MLC1 mutations, previously attributed to postnatal astrocyte dysfunction. Using patient-derived human cortical organoids, we show that MLC1...

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Literature Corpus work: c50f019a-1701-58f2-b089-198924c4e0ad
DOI: 10.1101/2025.04.16.647364

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