Article

Zebrafish <i>duox</i> mutations provide a model for human congenital hypothyroidism

2018-07-18

Abstract excerpt

<h4>ABSTRACT</h4> Thyroid dyshormonogenesis is a leading cause of congenital hypothyroidism, a highly prevalent but treatable condition. Thyroid hormone synthesis is dependent on the formation of reactive oxygen species (ROS). In humans, the primary sources for ROS production during thyroid hormone synthesis are the NADPH oxidase, DUOX1 and DUOX2. Indeed mutations in DUOX1 and DUOX2 have been linked with congen...

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Literature Corpus work: c5039ed0-e8f8-5b48-90ec-b58ffeb13d55
DOI: 10.1101/372003

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