Article

Context dependent isoform specific PI3K inhibition confers drug resistance in Hepatocellular carcinoma cells

2021-03-17

Abstract excerpt

<h4>Background</h4> Targeted therapies for Primary liver cancer (HCC) is limited to the multi-kinase inhibitors, and not fully effective due to the resistance to these agents because of the heterogeneous molecular nature of HCC developed during chronic liver disease stages and cirrhosis. Although combinatorial therapy can increase the efficiency of targeted therapies through synergistic activities, isoform specif...

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Literature Corpus work: c4ecdbe8-3268-5076-8330-48f5188719ae
DOI: 10.1101/2021.03.17.435839

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