Article

DNA Aptamer Raised against Advanced Glycation End Products Improves Sperm Concentration, Motility, and Viability by Suppressing RAGE-Induced Oxidative Stress and Inflammation in Testes of Diabetic Mice

2024-04-29

Abstract excerpt

Type 2 diabetes mellitus (T2DM) is a risk factor for male infertility, but the underlying molecular mechanisms remain unclear. Advanced glycation end products (AGEs) are pathogenic molecules for diabetic vascular complications. Here, we investigated the effects of DNA-aptamer raised against AGEs (AGE-Apt) on testicular and sperm abnormalities in a T2DM mouse model. KK-Ay (DM) and wild-type (non-DM) 4- and 7-week-o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c4a4923d-7c27-566a-890a-e9229e0ba0aa
DOI: 10.20944/preprints202404.1938.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

DNA Aptamer Raised against Advanced Glycation End Products Improves Sperm Concentration, Motility, and Viability by Suppressing RAGE-Induced Oxidative Stress and Inflammation in Testes of Diabetic MiceDOI 10.20944/preprints202404.1938.v1Read

Diabetic testicular dysfunction and spermatogenesis impairment: mechanisms and therapeutic prospectsSemantic proximity Read

Increased receptor for advanced glycation end products in spermatozoa of diabetic men and its association with sperm nuclear DNA fragmentationSemantic proximity Read

Impact of Dietary Advanced Glycation End Products on Female Reproduction: Review of Potential Mechanistic PathwaysSemantic proximity Read

Advanced glycation end products and their relevance in female reproductionSemantic proximity Read

Advanced glycation end products accumulate in the reproductive tract of men with diabetesSemantic proximity Read

The effects of diabetes on male fertility and epigenetic regulation during spermatogenesisSemantic proximity Read

Diabetes-Induced Autophagy Dysregulation Engenders Testicular Impairment via Oxidative StressSemantic proximity Read

Blockade of receptor for advanced glycation endproducts: a new target for therapeutic intervention in diabetic complications and inflammatory disorders.Semantic proximity Read

MiR‐92b‐3p is Induced by Advanced Glycation End Products and Involved in the Pathogenesis of Diabetic NephropathySemantic proximity Read

Elevated Levels of Urinary Markers of Oxidative DNA and RNA Damage in Type 2 Diabetes with ComplicationsSemantic proximity Read

Non-Coding RNAs: New Dawn for Diabetes Mellitus Induced Erectile DysfunctionSemantic proximity Read