Article

Unexpected Impairment of INa current Underpins Reentrant Arrhythmias in a Knock-in Swine Model of Timothy Syndrome

2023-02-09

Abstract excerpt

<title>Abstract</title> <p>Timothy Syndrome 1 (TS1) is a multiorgan form of Long QT Syndrome associated with life-threatening cardiac arrhythmias, the organ-level dynamics of which remain unclear. Here, we developed and characterized a novel porcine model of TS1 carrying the causative p.Gly406Arg mutation in <italic>CACNA1C</italic>, known to impair CaV1.2 channel inactivation. Our model fully recapitulated the h...

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Literature Corpus work: c38532b4-326d-560f-9216-efff45d331f7
DOI: 10.21203/rs.3.rs-2482900/v1

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