Article
LncRNA GAS5 attenuates fibroblast activation through inhibiting Smad3 signaling
2020-02-02
Abstract excerpt
Transforming Growth Factor β (TGF-β)-induced fibroblast activation is a key pathological event during tissue fibrosis. Long noncoding RNA (lncRNA) is a class of versatile gene regulators participating in various cellular and molecular processes. However, the function of lncRNA in fibroblast activation is still poorly understood. In this study, we identified growth arrest-specific transcript 5 (GAS5) as a novel reg...
Topics
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- Cancer-related molecular mechanisms research
- Cardiac Fibrosis and Remodeling
- Connective Tissue Growth Factor Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Liver physiology and pathology
- Pancreatic and Hepatic Oncology Research
- TGF-β signaling in diseases
- Transplantation: Methods and Outcomes
Identifiers and source
- Literature Corpus work
- c3814315-3edd-52c3-a81b-a3153b645c6f
- DOI
- 10.1101/2020.02.01.930412
