Article
Multi-population GWAS meta-analysis identifies bladder cancer susceptibility loci and highlights genetic regulation of smoking-related risk.
Nature communications - 8 Aug 2026
Prokunina-Olsson Ludmila, Florez-Vargas Oscar, Levin Michael G, Dutta Diptavo, Breeze Charles E, Hurwitz Lauren M, Yan Wusheng, Lamy Philippe, Papenberg Brenen W, Wang Kevin, Lee Chia-Han, Milne Roger L, Gu Jian, Um Caroline Y, Joseph Vijai, Furberg Helena, Le Calvez-Kelm Florence, Lori Adriana, Choudhury Parichoy Pal, Afshar Nina, Kogevinas Manolis, Offit Kenneth, Vermeulen Sita H, López de Maturana Evangelina, Albanes Demetrius, Purdue Mark P, Cortessis Victoria K, Karagas Margaret R, Kooperberg Charles, Bjurlin Marc, Tadesse Deborah A, Moore Steven C, Huang Wen-Yi, Haiman Christopher A, Stern Mariana C, Eliassen A Heather, Mucci Lorelei A, Aben Katja K, Galesloot Tessel E, Verma Anurag, Yoshino Soichiro, Hikino Keiko, Terao Chikashi, Rafnar Thorunn, Matsuda Koichi, Shuin Taro, Garcia-Closas Montserrat, Real Francisco X, Kiemeney Lambertus A, Chanock Stephen J, Malats Núria, Silverman Debra T, Dyrskjot Lars, Rothman Nathaniel, Damrauer Scott M, Koutros Stella, Damrauer Jeffrey S
Abstract excerpt
Bladder cancer is the ninth most common cancer worldwide, caused by genetic and environmental risk factors. Here, we report the findings of a multi-population meta-analysis of genome-wide association studies, including 32,470 individuals with and 1,753,462 without bladder cancer. We identify 70 independent risk loci, of which 43 are novel. Using a 70-marker polygenic risk score (HR = 1.63 per standard deviation),...
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