Article

A striking similarity in the organization of the E-selectin and beta interferon gene promoters.

1994-10-01

Abstract excerpt

Transcription of the endothelial leukocyte adhesion molecule 1 (E-selectin or ELAM-1) gene is induced by the inflammatory cytokines interleukin-1 beta and tumor necrosis factor alpha (TNF-alpha). In this report, we identify four positive regulatory domains (PDI to PDIV) in the E-selectin promoter that are required for maximal levels of TNF-alpha induction in endothelial cells. In vitro DNA binding studies reveal t...

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Literature Corpus work: c341a03d-3d17-5f12-b158-378c23918920
DOI: 10.1128/mcb.14.10.6464

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