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Carbohydrate consumption drives adaptive mutations in <i>Escherichia coli</i> associated with increased risk for systemic infection

2025-03-26

Abstract excerpt

Dissemination of organisms from the gut microbiota is a major contributor to sepsis and critical illness. Patients with cirrhosis are prone to systemic infections and are commonly prescribed the carbohydrate lactulose to manage hepatic encephalopathy (HE) 1 . Commensal metabolism of lactulose is believed to reduce pathobiont colonization through short-chain fatty acid production, but its direct effects on gut pat...

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Literature Corpus work
c32203b7-f444-500c-bf7d-aa73427a148d
DOI
10.1101/2025.03.26.645536
Open publication

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