Article

Frequency enrichment of coding variants in a French-Canadian founder population and its implication for inflammatory bowel diseases

2025-07-14

Abstract excerpt

1 The genetic features of founder populations with recent bottlenecks, causing some deleterious variants to rise to higher frequencies, can enhance the power of rare variant association studies. French Canadians from Quebec represent a recent founder population with a particular disease heritage comprising more than 30 prevalent Mendelian conditions. Here, we characterize coding variation in this founder populatio...

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Literature Corpus work: c2f9f30c-ce33-527c-83b0-8d217ba4ec7e
DOI: 10.1101/2025.07.11.25331388

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