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The Global Compatibility Index (GCI): A Variance-Weighted Pharmacogenomic Scoring System Demonstrates Near-Perfect Cross-Mode Consistency (ICC = 0.994) and Improves Warfarin Dose Prediction Over the CPIC Algorithm in 5,475 Patients Across Four Continents, with Multi-Drug Validation Across 10 Independent Datasets

2026-05-12

Abstract excerpt

<title>Abstract</title> <p> <bold>Background.</bold> Adverse drug reactions (ADRs) account for 10–15% of all hospital admissions globally, with the majority attributable to variants in pharmacogenomically actionable genes. Current decision tools require genomic sequencing infrastructure unavailable in over 80% of the world's healthcare settings, creating a profound global equity gap in personalised prescribing....

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Literature Corpus work: c2b630f4-c947-5c08-971e-48b28e910050
DOI: 10.21203/rs.3.rs-9454760/v1

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The Global Compatibility Index (GCI): A Variance-Weighted Pharmacogenomic Scoring System Demonstrates Near-Perfect Cross-Mode Consistency (ICC = 0.994) and Improves Warfarin Dose Prediction Over the CPIC Algorithm in 5,475 Patients Across Four Continents, with Multi-Drug Validation Across 10 Independent DatasetsDOI 10.21203/rs.3.rs-9454760/v1Read

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