Article

Combinatorial Targeting of Avapritinib-Driven MAP Kinase Activation in High-Grade Glioma

2026-06-24

Abstract excerpt

<title>Abstract</title> <p>PDGFRA alterations define a high-risk subset of high-grade glioma (HGG), yet targeted therapies have yielded limited and transient benefit. Here, we show that the CNS-penetrant PDGFRA inhibitor avapritinib induces sustained MAPK pathway activation at supratherapeutic dosing, revealing a therapy-induced adaptive vulnerability. High-dimensional kinome profiling (>900 nodes) and in vivo st...

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Literature Corpus work: c2a1c375-3b32-5bd2-b88a-fe0a3506cb3a
DOI: 10.21203/rs.3.rs-9974885/v1

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