Article

MiR-186 serves as a tumor suppressor in lung adenocarcinoma cells by down-regulation of Shp2 gene and inhibiting PI3K/Akt/mTOR signaling pathway

2020-03-11

Abstract excerpt

<title>Abstract</title> <p>Background The study aimed to investigate the effect and mechanism of miR-186, which targets protein tyrosine phosphatase (Shp2) PI3K/Akt/mTOR signaling pathway, on the biological characteristics of lung adenocarcinoma cells. Methods In this experimental study, Human lung adenocarcinoma cell line SPC-A-1 was grouped as Blank group, negative control (NC) group, miR-186 mimic group, miR-1...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c27c3216-998a-5ed3-8511-8f431b717823
DOI: 10.21203/rs.3.rs-16802/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MiR-186 serves as a tumor suppressor in lung adenocarcinoma cells by down-regulation of Shp2 gene and inhibiting PI3K/Akt/mTOR signaling pathwayDOI 10.21203/rs.3.rs-16802/v1Read

ID2 Inhibits Lung Adenocarcinoma Cell Malignant Behaviors Through Inhibiting the Activation of the PI3K/AKT/mTOR Signaling PathwaySemantic proximity Read

SIRT2 inhibits non-small cell lung cancer cell growth through impairing Skp2-mediated p27 degradationSemantic proximity Read

SPAG1 Inhibits Cell Proliferation and Tumor Growth of Lung Adenocarcinoma via the AKT/mTORC1 Signaling AxisSemantic proximity Read

miR-196b-5p Promotes Proliferation, Migration and Invasion of Lung Adenocarcinoma Cells via Targeting RSPO2Semantic proximity Read

MiR-182-5p Promotes The Metastasis and Epithelial-Mesenchymal Transition in Non-Small Cell Lung Cancer By Targeting EPAS1Semantic proximity Read

New development of inhibitors targeting the PI3K/AKT/mTOR pathway in personalized treatment of non-small-cell lung cancer.Semantic proximity Read

PIWIL2 interacting with IKK to regulate autophagy and apoptosis in esophageal squamous cell carcinomaSemantic proximity Read

Alteration of SHP-1/p-STAT3 Signaling: A Potential Target for Anticancer TherapySemantic proximity Read

SHP2 Inhibition Benefits Epidermal Growth Factor Receptor-mutated Non-Small Cell Lung Cancer Therapy.Semantic proximity Read

Cell specific tumor suppressor effect of Hsa-miR-1226-3p through downregulation of HER2, PIK3R2, and AKT1 genesSemantic proximity Read

Strategies to overcome drug resistance using SHP2 inhibitorsSemantic proximity Read

GTSE1 Facilitates the Malignant Phenotype of Lung Cancer Cells via Activating AKT/mTOR Signaling.Semantic proximity Read