Article

Therapeutic targeting of PFKFB3 and PFKFB4 in multiple myeloma cells under hypoxic conditions

2021-11-22

Abstract excerpt

<title>Abstract</title> <p>BackgroundMultiple myeloma (MM) is a hematological malignancy characterized by the clonal expansion of plasma cells in the bone marrow. The treatment of MM patients has been dramatically changed by new agents, such as proteasome inhibitors and immunomodulatory drugs; however, many patients will relapse, even if the new agents provide therapeutic advantages. Hypoxia is an important compo...

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Literature Corpus work: c22960c4-53ad-5b38-b909-45e337a2123d
DOI: 10.21203/rs.3.rs-1091276/v1

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