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Article

Impact of hypoxia on the pathogenesis and therapy resistance in multiple myeloma

26 Jul 2021

Abstract excerpt

Multiple myeloma (MM) is a refractory plasma cell tumor. In myeloma cells, the transcription factor IRF4, the master regulator of plasma cells, is aberrantly upregulated and plays an essential role in oncogenesis. IRF4 forms a positive feedback loop with MYC, leading to additional tumorigenic properties. In recent years, molecular targeted therapies have contributed to a significant improvement in the prognosis...

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PMID: 34310776
DOI: 10.1111/cas.15087

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