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Article

The EGFL7-ITGB3-KLF2 axis enhances survival of multiple myeloma in preclinical models

19 Mar 2020

Abstract excerpt

Angiogenic factors play a key role in multiple myeloma (MM) growth, relapse, and drug resistance. Here we show that malignant plasma cells (cell lines and patient-derived MM cells) express angiocrine factor EGF like-7 (EGFL7) mRNA and protein. MM cells both produced EGFL7 and expressed the functional EGFL7 receptor integrin β 3 (ITGB3), resulting in ITGB3 phosphorylation and focal adhesion kinase activation....

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PMID: 32191808
DOI: 10.1182/bloodadvances.2019001002

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